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Meta-analysis and Evidence-based Medicine Training in Cardiology



Protocol #5-2007 (ongoing)
Title: A systematic review and meta-analysis on simple versus complex stenting strategy for coronary bifurcation lesions in the drug-eluting stent era
Highlights: Randomized clinical trials comparing simple versus complex stenting strategy for coronary bifurcation lesions with drug-eluting stents will be systematically searched, appraised and pooled with meta-analytic methods
Principal investigator: Giuseppe Biondi Zoccai, University of Turin, Turin, Italy
PubMed search strategy: bifurcat* AND (drug OR sirolimus OR paclitaxel) AND elut* AND stent* AND coronary AND (randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized controlled trials[mh] OR random allocation[mh] OR double-blind method[mh] OR single-blind method[mh] OR clinical trial[pt] OR clinical trials[mh] OR (clinical trial[tw] OR ((singl*[tw] OR doubl*[tw] OR trebl*[tw] OR tripl*[tw]) AND (mask*[tw] OR blind[tw])) OR (latin square[tw]) OR placebos[mh] OR placebo*[tw] OR random*[tw] OR research design[mh:noexp] OR comparative study[tw] OR evaluation studies[mh] OR follow-up studies[mh] OR prospective studies[mh] OR cross-over studies[mh] OR control*[tw] OR prospectiv*[tw] OR volunteer*[tw]) NOT (animal[mh] NOT human[mh]) NOT (comment[pt] OR editorial[pt] OR meta-analysis[pt] OR practice-guideline[pt] OR review[pt]))

Protocol #4-2007 (published as Biondi-Zoccai et al, Am Heart J 2008)
Title: A systematic review and meta-analysis on the angiographic and clinical impact of cilostazol after percutaneous coronary intervention
Highlights: Randomized clinical trials comparing cilostazol to control after percutaneous coronary intervention will be systematically searched, appraised and pooled with meta-analytic methods
Principal investigator: Giuseppe Biondi Zoccai, University of Turin, Turin, Italy

Protocol #3-2007 (discontinued)
Title: A systematic review and meta-analysis comparing the diagnostic performance of multislice computed tomography versus conventional angiography to assess patency after coronary stent implantation
Highlights: Diagnostic studies comparing computed tomography versus conventional invasive coronary angiography in patients treated with stents will be systematically searched, appraised, and pooled with meta-analytic techniques when appropriate
Principal investigator: Giuseppe Biondi Zoccai, University of Turin, Turin, Italy
PubMed search strategy developed according to Haynes et al: (((computed AND tomography) OR ct OR cat OR angio-ct OR angioct) AND stent* AND angiography AND coronary) AND (sensitiv*[Title/Abstract] OR sensitivity and specificity[MeSH Terms] OR diagnos*[Title/Abstract] OR diagnosis[MeSH:noexp] OR diagnostic *[MeSH:noexp] OR diagnosis,differential[MeSH:noexp] OR diagnosis[Subheading:noexp])

Protocol #2-2007 (discontinued)
Title: When should systematic reviews in coronary heart disease be trusted? An appraisal on the impact of funding on validity and recommendations
Highlights: Systematic reviews published between 1999 and 2005 on coronary heart disease topics will systematically searched in the Database of Abstracts of Reviews of Effects (DARE), with validity, recommendations, and funding extracted and analyzed on the basis of the structured abstracts included in DARE
Principal investigator: Giuseppe Biondi Zoccai, University of Turin, Turin, Italy
DARE search strategy: ((myocard* OR cardiac OR heart) AND (infarction OR angina OR ischemia)) OR (coronary AND artery AND disease)

Protocol #1-2007 (published as Abbate et al, J Am Coll Cardiol 2008, and Appleton et al, Catheter Cardiovasc Interv 2008)
Title: Late percutaneous coronary intervention following acute myocardial infarction: a meta-analysis of the effects on cardiac function and remodeling
Highlights: Clinical trials comparing late percutaneous coronary intervention versus best medical therapy after acute myocardial infarction will be systematically searched, appraised, and pooled when appropriate, focusing on cardiac remodeling parameters
Principal investigator: Antonio Abbate, Virginia Commonwealth University, Richmond, VA, USA
The spreadsheet macro used to impute differences across groups in agreement with Thiessen Philbrook et al is available online (15 Kb Xls file)



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