metcardio.org
 Meta-analysis and Evidence-based Medicine Training in Cardiology
The metcardio.org website is dedicated to meta-analysis and evidence-based medicine training in cardiology. It is sponsored by the Meta-analysis and Evidence-based medicine Training in Cardiology (METCARDIO) Group, currently headquartered in Turin, Italy, and formerly known as the Center for Overview, Meta-analysis, and Evidence-based Medicine Training (COMET). The focus of the metcardio.org website is on clinical research methods and evidence-based cardiovascular medicine with a specific interest in interventional cardiology and peripheral cardiovascular interventions. Nonetheless, there is plenty of training and research opportunities for other evidence-based endeavors, eg in anesthesiology, critical care medicine, and psychiatry.


Title: Systematic review of controlled clinical trials on pharmacologic treatments for acute nontubercolous pericarditis and its recurrences
PubMed search strategy: (pericarditis OR (inflammation AND (pericardium OR pericardial OR pericard* OR (tamponade)))) AND (randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized controlled trials[mh] OR random allocation[mh] OR double-blind method[mh] OR single-blind method[mh] OR clinical trial[pt] OR clinical trials[mh] OR (clinical trial[tw] OR ((singl*[tw] OR doubl*[tw] OR trebl*[tw] OR tripl*[tw]) AND (mask*[tw] OR blind[tw])) OR (latin square[tw]) OR placebos[mh] OR placebo*[tw] OR random*[tw] OR research design[mh:noexp] OR comparative study[tw] OR follow-up studies[mh] OR prospective studies[mh] OR cross-over studies[mh] OR control*[tw] OR prospectiv*[tw] OR volunteer*[tw]) NOT (animal[mh] NOT human[mh]) NOT (comment[pt] OR editorial[pt] OR meta-analysis[pt] OR practice-guideline[pt] OR review[pt]))
Principal investigator: Giuseppe Biondi Zoccai, University of Turin, Turin, Italy

Title: Systematic review on percutaneous transluminal stenting for below-the-knee atherosclerotic disease
Highlights: Clinical studies focusing on below-the-knee stenting for critical limb ischemia will be systematically searched, appraised and pooled with meta-analytic techniques
PubMed search strategy: stent* AND (cli OR btk OR infragenicular OR infrapopliteal OR tibial OR peroneal OR (critical AND limb AND (ischemia OR ischaemia)) OR (below AND knee) OR (infra AND popliteal) OR (infra AND genicular))
Principal investigator: Giuseppe Biondi Zoccai, University of Turin, Turin, Italy
Primary authors of the original clinical studies wishing to submit additional or missing data should refer to appropriate online form (75 Kb Rtf file)

Title: Individual patient-data meta-analysis comparing long-term clinical outcome in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention with or without prior thrombectomy
Highlights: Randomized clinical trials comparing percutaneous coronary intervention with or without prior thrombectomy in patients with with ST-elevation myocardial infarction will be systematically searched, appraised and pooled at the patient level with meta-analytic methods
Principal investigators: Francesco Burzotta and Maria De Vita, Catholic University, Rome, Italy

Title: A systematic review and meta-analysis on antidepressant medications versus control treatment in patients with acute coronary syndromes
Highlights: Randomized clinical trials comparing antidepressant medications versus control treatment in patients with acute coronary syndromes will be systematically searched, appraised and pooled with meta-analytic methods
Principal investigator: Marianna Mazza, Catholic University, Rome, Italy
PubMed search strategy: antidepressant[mesh] OR ((treatment OR therapy) AND (depression OR depressive)) OR antidepressant OR ssri) AND ((angina OR coronary) AND (unstable OR acute) OR (myocardial AND infarction)) AND (randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized controlled trials[mh] OR random allocation[mh] OR double-blind method[mh] OR single-blind method[mh] OR clinical trial[pt] OR clinical trials[mh] OR (clinical trial[tw] OR ((singl*[tw] OR doubl*[tw] OR trebl*[tw] OR tripl*[tw]) AND (mask*[tw] OR blind[tw])) OR (latin square[tw]) OR placebos[mh] OR placebo*[tw] OR random*[tw] OR research design[mh:noexp] OR comparative study[tw] OR evaluation studies[mh] OR follow-up studies[mh] OR prospective studies[mh] OR cross-over studies[mh] OR control*[tw] OR prospectiv*[tw] OR volunteer*[tw]) NOT (animal[mh] NOT human[mh]) NOT (comment[pt] OR editorial[pt] OR meta-analysis[pt] OR practice-guideline[pt] OR review[pt]
The spreadsheet macro used to impute differences across groups in agreement with Thiessen Philbrook et al is available online (15 Kb Xls file)

Title: A systematic review and meta-analysis on the diagnostic and prognostic impact of brain natriuretic peptide levels in patients with suspected or documented acute pulmonary embolism
Highlights: Clinical studies appraising the diagnostic and prognostic impact of brain natriuretic peptide levels in patients with suspected or documented acute pulmonary embolism will be systematically searched, appraised and pooled with meta-analytic methods
Principal investigator: Marzia Lotrionte, Catholic University, Rome, Italy